Preheat your oven to 350°F (175°C).

In a large pot, bring salted water to a boil. Add 1 pound of elbow macaroni and cook until al dente, about 8-10 minutes. Drain and set aside.

In a saucepan over medium heat, melt ½ cup of unsalted butter, then whisk in ½ cup of all-purpose flour for about 2 minutes until light golden.

Gradually whisk in 4 cups of whole milk into the roux for 5-7 minutes until thickened and bubbling.

Remove from heat, add garlic powder, onion powder, mustard powder, salt, and pepper. Fold in the shredded cheeses until smooth.

Gently mix in the drained macaroni into the cheese sauce until well coated.

In a bowl, mix 1 cup of panko breadcrumbs with ½ cup of grated Parmesan cheese and a drizzle of melted butter.

Pour the mac and cheese mixture into a greased 9×13-inch baking dish and top with the breadcrumb mixture.

Bake for 25-30 minutes until golden brown and bubbling.

Let cool slightly, sprinkle with parsley, and serve.